Welcome to the Risk Project 

The contribution of ventricular arrhythmia to morbidity and mortality in the elderly is substantial. Sudden cardiac death (SCD) is one of the most important causes of cardiovascular death with an incidence rate of one per 1000 patient years. SCD and non-fatal ventricular arrhythmia as a consequence of repolarization disturbances are frequent adverse effects of many commonly used drugs (e.g. antiarrhythmics, antidepressants, antipsychotics, antihistamines, certain antibiotics) in the elderly.

QT interval prolongation is the main parameter measured to assess the arrhythmogenic potential of drugs, but fails to adequately predict the risk of sudden cardiac death associated with drug use. Several other ECG parameters have been proposed, e.g, beat-to-beat changes of the QT interval, and heart rate variability. In addition, there are other effect modifiers, e.g., genetic variants and metabolic parameters.


The objective of the Risk-Project is to improve the insight in risk factors for Sudden Cardiac Death